The HA1 structure for H1~H16 used in this study:

H1 H2 H3 H4 H5 H6 H7 H8

H9 H10 H11 H12 H13 H14 H15 H16

The Artificial sites for H1~H16 defined in this study based on the distance of amino acid position to the top of HA1 protein (according to Lees’s work):

H1 H2 H3 H4 H5 H6 H7 H8

H9 H10 H11 H12 H13 H14 H15 H16

The representative sequences for H1~H16 used in this study:

H1 H2 H3 H4 H5 H6 H7 H8

H9 H10 H11 H12 H13 H14 H15 H16

The antigenic data used for building this web server:

H1N1 H3N2 H5N1 H9N2